Bladder instability and detrusor smooth muscle function
نویسندگان
چکیده
منابع مشابه
Bladder Alterations Induced by Detrusor Instability
Objectives: The aim of this study was to evaluate the histopathological and immunohistochemical alterations induced by detrusor instability in the bladder of rabbits submitted to partial bladder outlet obstruction. Materials and Methods: Thirty male Norfolk rabbits were divided into 2 groups, a clinical control and a group with detrusor instability. Urine culture, cystometric study, histopathol...
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TRPA1 is a Ca(2+)-permeable cation channel that is activated by painful low temperatures (<17°C), irritating chemicals, reactive metabolites and mediators of inflammation. In the bladder TRPA1 is predominantly expressed in sensory afferent nerve endings, where it mediates sensory transduction. The contractile effect of its activation on detrusor smooth muscle (DSM) is explained by the release f...
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Comment The toxic shock syndrome was first reported in seven children in 19782; in five of these Staphylococcus aureus was isolated from various sites. The occurrence of toxic shock syndrome in menstruating women was first reported in 19803; since then 299 cases have been reported in the United States with 25 deaths.4 About 95, of these cases have occurred in menstruating women, all of whom had...
متن کاملAlteration in expression of myosin isoforms in detrusor smooth muscle following bladder outlet obstruction.
Partial urinary bladder outlet obstruction (PBOO) in men, secondary to benign prostatic hyperplasia, induces detrusor smooth muscle (DSM) hypertrophy. However, despite DSM hypertrophy, some bladders become severely dysfunctional (decompensated). Using a rabbit model of PBOO, we found that although DSM from sham-operated bladders expressed nearly 100% of both the smooth muscle myosin heavy chain...
متن کاملLarge-conductance voltage- and Ca2+-activated K+ channels regulate human detrusor smooth muscle function.
The large-conductance voltage- and Ca(2+)-activated K(+) (BK) channel is expressed in many smooth muscle types, but its role in human detrusor smooth muscle (DSM) is unclear. With a multidisciplinary approach spanning channel molecules, single-channel activity, freshly isolated human DSM cells, intact DSM preparations, and the BK channel specific inhibitor iberiotoxin, we elucidated human DSM B...
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ژورنال
عنوان ژورنال: Experimental Physiology
سال: 1999
ISSN: 0958-0670
DOI: 10.1111/j.1469-445x.1999.tb00081.x